Content

TECHOLOGY PLATFORMS

The expertise of individual RTG labs in state-of-the-art techniques as well as in disease mouse models will further promote and expand collaborations between the individual projects. Examples are:

  • the generation of transgenic and knock out mouse models via the CRISP/Cas9 technology
  • CRISPR/Cas-mediated gene modifications of primary immune cell populations
  • metabolic analyses, e.g., by the Seahorse technology
  • multiphoton microscopy
  • bioinformatics analysis of RNA-seq, scRNA-seq (10x platform) and antibody repertoire data
  • a transgenic human antibody mouse, the so-called Trianni platform, to produce human antibodies and perform human antibody repertoire studies in mice
  • various mouse models for autoimmune (e.g., EAE, SLE), chronic inflammatory (arthritis, gut, and liver inflammation), tumor, and infectious diseases (mycobacteria, CMV, LCMV, helminths)